|
The following table of
FDA approved doses has been created to assist in converting nonformulary
medications to equivalent regimens of formulary sulfonylureas at the
University of Kentucky Hospital.
|
Drug |
Equivalent Daily Dose |
Frequency |
Usual Dosage Range |
|
First Generation
Sulfonylureas |
|
Acetohexamide
(Dymelor®) |
500 mg |
QD-BID |
0.25-1.5 g |
|
Chlorpropamide
(Diabinese®) |
100-250 mg |
QD |
0.1-0.5 g |
|
Tolazamide (Tolinase®) |
250 mg |
QD-BID |
0.2-1 g |
|
Tolbutamide
(Orinase®) |
1000 mg |
BID-TID |
0.5-3 g |
|
Second Generation
Sulfonylureas |
|
Glimepiride (Amaryl®) |
2
mg |
QD |
1-8 mg |
|
Glipizide (Glucotrol®) |
5-10 mg |
QD-BID |
2.5-40 mg |
|
Glipizide extended release (Glucotrol
XL®) |
5
mg |
QD |
5-20 mg |
|
Glyburide (Diabeta®,
Micronase®) |
2.5-5 mg |
QD-BID |
1.25-20 mg |
|
Micronized glyburide (Glynase
PresTab®) |
3
mg |
QD |
1.0-12 mg |
*Italicized agents are
non-formulary
Prepared by: Kristal Williams, Pharm.D.
|
