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Sulfonylurea Dosage Conversion Table

The following table of FDA approved doses has been created to assist in converting nonformulary medications to equivalent regimens of formulary sulfonylureas at the University of Kentucky Hospital.

Drug Equivalent Daily Dose Frequency Usual Dosage Range
First Generation Sulfonylureas
 Acetohexamide (Dymelor) 500 mg QD-BID 0.25-1.5 g
 Chlorpropamide (Diabinese) 100-250 mg QD 0.1-0.5 g
 Tolazamide (Tolinase) 250 mg QD-BID 0.2-1 g
 Tolbutamide (Orinase) 1000 mg BID-TID 0.5-3 g

Second Generation Sulfonylureas

 Glimepiride (Amaryl) 2 mg QD 1-8 mg
 Glipizide (Glucotrol) 5-10 mg QD-BID 2.5-40 mg
 Glipizide extended release (Glucotrol XL) 5 mg QD 5-20 mg
 Glyburide (Diabeta, Micronase) 2.5-5 mg QD-BID 1.25-20 mg
 Micronized glyburide (Glynase PresTab) 3 mg QD 1.0-12 mg

*Italicized agents are non-formulary

Prepared by: Kristal Williams, Pharm.D.

Written: 4/00 | Posted on: 8/02 | For Internal University of Kentucky Chandler Medical Center Use Only

Comments to Kelly Smith, Pharm.D., Last Modified: August 13, 2006
Copyright 2002, University of Kentucky Chandler Medical Center
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